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The combination of plavix (clopidogrel) and eliquis (apixaban) is typically prescribed for patients with both atrial fibrillation requiring anticoagulation and recent coronary stent placement requiring antiplatelet therapy. Patients should not be on both plavix and eliquis simultaneously without a clear clinical indication and close monitoring, as the risks of bleeding complications are significant, and the benefits of combination therapy should be carefully weighed against these risks, as discussed in 1 and 1. In the past 5 years, a number of randomized clinical trials have explored different combinations of anticoagulation plus antiplatelet agents aimed at minimizing bleeding risk while preserving low thrombotic event rates.

Patients can develop independent indications for antiplatelet and oral anticoagulant therapy, but in most cases the pathophysiology will intersect. While eliquis is used to prevent and treat blood clots in situations like atrial fibrillation, deep vein thrombosis, and stroke, plavix is used to reduce clotting in situations like heart attacks, strokes, and the peripheral arteries of our limbs. Antiplatelet therapy for patients who have an acute coronary syndrome helps to prevent future cardiovascular events

This benefit can be increased by using two antiplatelet drugs

The choice of drug is determined for each individual patient. Plavix (clopidogrel) and eliquis (apixaban) are both blood thinners, but they work in fundamentally different ways They are prescribed to reduce the risk of dangerous blood clots, but their mechanisms, indications, and effects vary significantly. Plavix and eliquis treat different health conditions

Plavix helps prevent heart attacks and strokes if you’ve already had one or are at high risk for them Eliquis treats and prevents blood clots in the legs and lungs caused by surgery, an irregular heartbeat, or if you’ve had a blood clot before. According to the study results, patients taking apixaban saw a 31% reduction in risk versus those taking warfarin Additionally, patients taking placebo instead of aspirin saw a 47% reduction in bleeding risk compared with those taking aspirin.

Both eliquis and plavix are anticoagulant medications that work by preventing the formation of blood clots

While this can be beneficial in certain situations, it can also increase the risk of bleeding, including internal bleeding and gastrointestinal bleeding.

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