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Genetic factors exert a significant influence on cortisol levels in people Minimizing stress and adopting healthy habits may support balanced cortisol levels. Scientific research shows genetic factors explain roughly 60% of individual variation in blood cortisol levels.

The aim of the current study was to focus on indices of cortisol production and metabolism across adolescence, and to estimate the relative contributions of genetic and environmental factors to cortisol production and metabolism in a sample of children who were registered at birth in the netherlands twin register (ntr). Genetics and environmental factors, including exposure to early life stress, can influence cortisol levels and stress reactivity across the lifespan Stress affects everyone differently, and genetics play a key role in how our bodies regulate cortisol

Variants in genes like fkbp5 and crhr1 can lead to heightened cortisol sensitivity, making some individuals more prone to prolonged stress responses.

Genetic mutations in genes involved in adrenal cortex steroidogenesis can disrupt the synthesis and regulation of cortisol, aldosterone, and adrenal androgens, resulting in adrenal insufficiency and related symptoms. When you are stressed, your adrenal glands produce cortisol This applies to both physical stress, like running away from a tiger, or emotional stress, such as when you mess something up at work Your brain controls the release of cortisol from the adrenal glands.

Your genes can affect how efficiently your body processes cortisol and carries out methylation Some people may be more prone to mood changes, fatigue, or inflammation because of genetic variants that affect these pathways. Despite the large amount of volunteer data used, no new genetic variants were found to influence cortisol levels However, that doesn't mean that the genes aren't there to be found

So, research into what genes might affect cortisol levels continues.

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