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This phase ii trial tests the safety and side effects of low dose capecitabine and how well it works in treating older patients with her2 negative breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic) Fda also approved the guardant360 cdx assay as a companion diagnostic device to identify patients with breast cancer with esr1 mutations for treatment with imlunestrant. Capecitabine is in a class of medications called antimetabolites.

The treatment included a histone deacetylase (hdac) inhibitor — a drug that causes a. The tolerability of this drug with the oral chemotherapy capecitabine is. Current clinical trials and their implications for cdk4/6 inhibitor therapy and beyond treatment options.

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